FORMULATION AND CARACTERIZATION OF QUERCETIN NIOSOME WITH CONCENTRATION VARIATIONS OF SPAN 20 SURFACTANT

Quercetin has low solubility, absorption and bioavailability which limits its practical use as a drug or supplement. Therefore, it is important to formulate quercetin niosome system with various concentrations of span 20 surfactant. This investigation aimed analyse preparation variations provide optimal solubility. Niosomes were prepared using 20. In the present study, used reverse phase evaporation (RPE) method. characterised by organoleptic properties, pH value, particle morphology comprising shape size, encapsulation efficiency. Organoleptic observations included yellow colour, distinctive odour thick consistency for all formulas. The remained within physiological range skin. was close spherical while size results 2.13 µm (F1), 2.99 (F2) 3.31 (F3). efficiency 81.86 ± 0.47% 84.02 0.26% 88.24 0.10% successfully multiple below cholesterol concentration measurement organoleptic, pH,